Parenting is arguably the most critical factor in protecting teenagers from problem behaviours, such as delinquency and substance use. For immigrant mothers, however, the ability to care for their children might be negatively affected by challenges related to acculturation and area deprivation. The aim of this study was to raise this issue by examining parenting challenges and needs among immigrant mothers of teenagers living in disadvantaged neighbourhoods in Sweden. Such knowledge is crucial for society to be able to adequately support families in promoting their teenagers well-being. Based on an intersectional framework and qualitative interviews with 14 mothers, four themes related to challenges and needs emerged: structural challenges, cultural transition, psychosocial problems, and social support. The themes were highly intertwined and demonstrated substantial distress among immigrant mothers in relation to their parenting and protecting their children. Mothers’ were, therefore, highly engaged in parenting and expressed a desire and motivation to improve their parenting through social support. The introduction of culturally sensitive parenting support specifically aimed at this marginalized group of parents is encouraged.