Background: Major depressive disorder is one of the leading diseases in the world. While anti-depressive medication is the most commonly used treatment, studies shows conflicting results of its benefits, where other alternative treatments are getting more attention such as psychological treatment and physical activity.

Aim: The study aimed to illuminate the meaning of physical activity for adult patients suffering from major depressive disorder.

Method: The method used is a literature review of nine original scientific articles, published in Cinahl, PubMed and PsycArticles databases between 2010-2020, limited to peer-review and English language.

Results: The result showed a decrease in depressive symptoms as shown in rating scales such as HDRS, BDI and MADRS, in patients treated with physical activity. Patients suffering from severe major depressive disorder showed paramount difference pre-post intervention, despite their initial state of disability.

Conclusion: Regardless of the severity of disease, physical activity shows a valid effect as an adjunct treatment in adults suffering from major depressive disorder. The result shows that while the use of physical activity as therapy is warranted in patients with major depressive disorder, adherence to treatment is of outmost importance, and the support from health professionals is mandatory.