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  • 51. Hagman, U
    et al.
    Danfors, S
    Eriksson, HB
    Bruce, Å
    Gustavsson, L
    Persson, L-Å
    Samuelson, Gösta
    Sjölin, S
    Svenska barns kost och hälsa: presentation från en multicenterstudie 1980-1981. II Livsmedelsval och måltidsordning1982Conference paper (Other academic)
  • 52. Hagman, U
    et al.
    Persson, L-Å
    Samuelson, Gösta
    Sjölin, S
    Svenska barns kost och hälsa: resultat från en multicenterstudie 1980-1981. VII Dag-till-dag variationer i kosten1983Conference paper (Other academic)
  • 53. Hambraeus, L
    et al.
    Holmgren, G
    Samuelson, Gösta
    Dietary treatment of adult patients with phenylketonuria1971In: Nutrition and metabolism, ISSN 0029-6678, Vol. 13, no 5, p. 298-317Article in journal (Refereed)
  • 54. Hambraeus, L
    et al.
    Holmgren, G
    Samuelson, Gösta
    Ska äldre PKU-patienter behandlas?: [Should older patients with PKU be diet treated?].1974In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 71, no 12, p. 1183-4Article in journal (Refereed)
  • 55. Hedgran, M
    et al.
    Samuelson, Gösta
    Barnundersökningen 1980-811991In: Vår föda, ISSN 0042-2657, Vol. 43, no 1, p. 6-7Article in journal (Other academic)
  • 56. Hedgren, M
    et al.
    Arvidsson Lenner, R
    Samuelson, Gösta
    A dietary survey in adolescents: Methodological aspects of a 7-day food record1995In: Scandinavian Journal of Nutrition, ISSN 1102-6489, Vol. 39, no 2, p. 60-65Article in journal (Refereed)
  • 57. Hedgren, M
    et al.
    Samuelson, Gösta
    Sjukhuskost för barn och ungdom: En jämförelse mellan allmän kost och diabeteskost1991In: Näringsforskning, ISSN 0465-7675, Vol. 35, no 3, p. 111-115Article in journal (Other academic)
  • 58. Hellerud, C
    et al.
    Wramner, N
    Erikson, A
    Johansson, A
    Samuelson, Gösta
    Lindstedt, S
    Glycerol kinase deficiency: follow-up during 20 years, genetics, biochemistry and prognosis.2004In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 93, no 7, p. 911-21Article in journal (Refereed)
    Abstract [en]

    AIM: To follow two children with isolated glycerol kinase deficiency (GKD) with severe symptoms into adulthood.

    METHODS: The patients were followed during approximately 20 y and interviewed about symptoms, diet and physical activity. Fasting provocations, bicycle ergometer tests, dietary registrations, enzyme and mutation analysis were performed by standard protocols.

    RESULTS: The activity of glycerol kinase (GK) in fibroblasts was <10% of reference. One case had a deletion of exon 17, the other a mutation in exon 7 of the GK gene (601 A-->G). Both mothers were heterozygotes. Two maternal male cousins in one of the families were hemizygotes without symptoms. Tests performed in childhood documented pronounced sensitivity to fasting and physical exercise, whereas such tests at 23 and 31 y of age were essentially normal but with pronounced ketonaemia. After puberty, the boys had no hypoglycaemic symptoms and now report no problems with their condition; thus, their phenotype has changed over time.

    CONCLUSION: The greater importance of glycerol as a gluconeogenetic substrate in children than in adults may explain the episodes in young patients with GKD, often elicited by catabolic stress. With meals at frequent intervals, access to glucose and avoidance of strenuous sports, the prognosis is good for a normal adult life of a young child with isolated GKD and symptoms of hypoglycaemia.

  • 59. Hermansson, B
    et al.
    Holmgren, G
    Samuelson, Gösta
    Juvenile diabetes mellitus and atopy.1971In: Human Heredity, ISSN 0001-5652, E-ISSN 1423-0062, Vol. 21, no 5, p. 504-8Article in journal (Refereed)
  • 60. Hjelm, M
    et al.
    Samuelson, Gösta
    A biochemical study of erythrocytes in Swedish families with beta-thalassaemia minor.1974In: Scandinavian journal of haematology, ISSN 0036-553X, Vol. 13, no 2, p. 101-9Article in journal (Refereed)
  • 61. Hofsten, Kristina
    et al.
    Samuelson, Gösta
    Blåberg, Anette
    Laga babymaten själv: för barn upp till 1 1/2 år1997Book (Other (popular science, discussion, etc.))
  • 62. Holm, A K
    et al.
    Blomquist, H K
    Crossner, C G
    Grahnén, H
    Samuelson, Gösta
    A comparative study of oral health as related to general health, food habits and socioeconomic conditions of 4-year-old Swedish children.1975In: Community Dentistry and Oral Epidemiology, ISSN 0301-5661, E-ISSN 1600-0528, Vol. 3, no 1, p. 34-9Article in journal (Refereed)
  • 63. Holm, A K
    et al.
    Samuelson, Gösta
    [Dietary counseling in child health and dental services - a presentation of a diet case record].1981In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 78, no 3, p. 151-2Article in journal (Refereed)
  • 64. Holm, A K
    et al.
    Samuelson, Gösta
    Uhrbom, E
    [Dietary formulas for adults].1983In: Tandläkartidningen, ISSN 0039-6982, Vol. 75, no 8, p. 442-3Article in journal (Refereed)
  • 65. Holm, A-K
    et al.
    Samuelson, Gösta
    Dietary habits and dental caries in the northern part of Sweden during the last 50 years.1982Report (Other academic)
  • 66. Holm, AK
    et al.
    Samuelson, Gösta
    Uhbom, E
    Kostvaneformulär för vuxna.1983In: Tandläkartidningen, ISSN 0039-6982, Vol. 75, no 8Article in journal (Other academic)
  • 67. Holm, Anna-Karin
    et al.
    Johansson, Eivor
    Månsson, Britta
    Osland Johansson, Turid
    Samuelson, Gösta
    Kostanamnes för barn1980In: Tandläkartidningen, ISSN 0039-6982, Vol. 72, no 13-14, p. 736-740Article in journal (Other academic)
  • 68. Holm, Ann-Karin
    et al.
    Samuelson, Gösta
    Kostrådgivning inom hälso- och tandhälsovård för barn: förslag till kostanemnesformulär1981In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, no 3, p. 151-152Article in journal (Other academic)
  • 69. Holmgren, G
    et al.
    Blomquist, H K
    Samuelson, Gösta
    Positive effect of a late introduced modified diet in an 8-year-old pku child.1980In: Neuropadiatrie, ISSN 0028-3797, Vol. 11, no 1, p. 76-9Article in journal (Refereed)
    Abstract [en]

    A modified low phenylalanine diet was instituted in an 8-year-old PKU boy earlier untreated and mentally retarded. The boy was treated during a ten year observation period. A marked progress in mental capacity and in IQ scoring was seen. The difficulties in objective evaluation of the benefit of late introduced treatment with a diet low in phenylalanine is discussed.

  • 70. Holmgren, G
    et al.
    Hörnström, T
    Johansson, S
    Samuelson, Gösta
    Primary hyperoxaluria (glycolic acid variant): a clinical and genetical investigation of eight cases.1978In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 83, no 1, p. 65-70Article in journal (Refereed)
    Abstract [en]

    The clinical features of eight cases of primary hyperoxaluria have been summarized. The possibility of different phenotypes is discussed. A reduction, but no normalization, of the oxalate formation during pyridoxine therapy was found. A renal transplantation performed in one of the patients failed because of the formation of nephrocalcinosis.

  • 71. Holmgren, G
    et al.
    Jeppson, J O
    Samuelson, Gösta
    High-voltage electrophoresis in urinary amino acid screening1970In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 26, no 4, p. 313-318Article in journal (Refereed)
  • 72. Holmgren, G
    et al.
    Samuelson, Gösta
    Hermansson, B
    The prevalence of diabetes mellitus: a study of children and their relatives in a northern Swedish county.1974In: Clinical Genetics, ISSN 0009-9163, E-ISSN 1399-0004, Vol. 5, no 5, p. 465-8Article in journal (Refereed)
  • 73. Holmgren, G
    et al.
    Samuelson, Gösta
    Sjögren, S
    Treatment of a presymptomatic 14-year-old girl with Wilson's disease.1982In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 87, no 1, p. 91-6Article in journal (Refereed)
  • 74. Holmgren, Gösta
    et al.
    Samuelson, Gösta
    Sjögren, Stellan
    Treatment of a presymptomatic 14-year-old girl with Wilson's disease.1982In: Upsala journal of medical sciences, ISSN 0300-9734, Vol. 87, no 1, p. 91-96Article in journal (Other academic)
  • 75.
    Hoppe, Michael
    et al.
    Department of Gastroenterology and Hepatology , Clinical Nutrition Unit , Sahlgrenska University Hospital , Gothenburg , Sweden.
    Hulthén, Lena
    University of Gothenburg , Department of Internal Medicine and Clinical Nutrition , Sahlgrenska Academy , Gothenburg , Sweden.
    Samuelson, Gösta
    University West, Department of Health Sciences, Section for nursing - graduate level. Uppsala University , Department of Clinical Sciences/Clinical Physiology , Uppsala , Sweden..
    Is cord blood hepcidin influenced by the low-grade acute-phase response occurring during delivery?: A small-scale longitudinal study2019In: The Journal of Maternal-Fetal & Neonatal Medicine, ISSN 1476-7058, E-ISSN 1476-4954, Vol. 32, no 13, p. 2166-2172Article in journal (Refereed)
    Abstract [en]

    AIM: To measure serum hepcidin in late pregnancy and in cord blood, and to analyze relationship between hepcidin, interleukin-6 and biomarkers of fetal iron status.

    MATERIALS AND METHODS: Data from 15 uncomplicated singleton pregnancies were analyzed longitudinally in trimester 3 (T3) and at birth.

    RESULTS: In T3, S-ferritin (median 14 µg/L) and transferrin (median 4.0 g/L) indicated low iron status, whereas the median soluble transferrin receptor (sTfR) was 4.0 mg/L, ie within the reference interval. Median T3 S-hepcidin was 7.8 ng/mL. Later on in cord blood, ferritin concentration (180 µg/L) were significantly higher, transferrin concentration (1.8 g/L) were significantly lower, and both sTfR (4.7 mg/L) and S-hepcidin concentrations (30.5 ng/mL) were significantly higher than maternal T3 concentrations. At the same time, cord blood interleukin-6 indicated an activated acute-phase reaction. In T3, after logarithmic transformation, there was a significant correlation between S-hepcidin and both S-ferritin (r = 0.691) and sTfR (r = -0.825). There was also a significant correlation between S-ferritin and both sTfR (r = -0.729) and transferrin (r = 0.549) in T3.

    CONCLUSIONS: Although S-ferritin, S-hepcidin, and sTfR were correlated during pregnancy, these relationships were not apparent in umbilical cord blood. Further, cord blood interleukin-6 indicated an activated acute-phase response, and sTfR, which is known to be unaffected by inflammation, indicated a low iron status in cord blood. Thus, instead of representing an enhanced iron status, the data appear to suggest that hepcidin and ferritin in cord blood may be influenced by the low-grade acute-phase response that occurs during delivery.

  • 76. Höglund, D
    et al.
    Samuelson, Gösta
    Mark, A
    Food habits in Swedish adolescents in relation to socioeconomic conditions.1998In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 52, no 11, p. 784-9Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To describe the food habits of Swedish adolescents 14-15 y of age. To analyse the connection between food habits and socioeconomic circumstances and background factors.

    DESIGN: Cross-sectional survey using a Food Frequency Questionnaire including questions on meal patterns.

    SETTING: The city of Göteborg and the County of Alvsborg, Sweden 1996.

    SUBJECTS: Pupils in the 8th grade in all schools in the city of Göteborg and the County of Alvsborg were in February 1996 invited to participate. The study comprised 7605 pupils. The drop-out rate was 14.4% (n = 1280).

    RESULTS: The adolescents had an infrequent consumption of vegetables and fruits and they had a daily consumption of sweets. Cereals, dairy products and snacks: buns, wafers, soft drinks, ice cream and potato crisps were consumed more than once a day. Thirty percent of the girls and 20% of the boys did not eat breakfast every day. The free school lunch was eaten daily by 50% of the boys and 30% of the girls, the remainder ate some type of snack. A negative correlation was found between smoking and the frequency of vegetable consumption. Pupils from areas with high socioeconomic status more often ate breakfast and lunch and the boys more often ate dinner compared to adolescents from areas with low socioeconomic status.

    CONCLUSIONS: An irregular meal pattern as well as snack consumption and smoking were common, especially among girls in areas with low socioeconomic status.

  • 77. Höyer, S
    et al.
    Samuelson, Gösta
    Först att påvisa glykogeninlagring vid hjärtförstoring - fick en våldsam död framför en exekutionspluton.1986In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 83, no 16, p. 1477-1479Article in journal (Other academic)
  • 78. Höyer, S
    et al.
    Samuelson, Gösta
    [The man behind the syndrome: Joannes Cassianus Pompe. The first person to determine glycogen storage in heart enlargement--he died violently before an execution squad].1986In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 83, no 16, p. 1477-9Article in journal (Refereed)
  • 79. Isaksson, Björn
    et al.
    Hambraeus, Leif
    Vinnars, Erik
    Samuelson, Gösta
    Larsson, Jörgen
    Asp, Nils-Georg
    In memory of Arvid Wretlind 1919-20022002In: Scandinavian Journal of Nutrition/Næringsforskning, ISSN 1102-6480, E-ISSN 1651-2359, Vol. 46, no 3, p. 117-117Article in journal (Other academic)
  • 80. Jagell, Sven
    et al.
    Samuelson, Gösta
    Gruppundervisning av medicine kandiater med hjälp av diabilder1976Report (Other academic)
  • 81. Jonsell, R
    et al.
    Frankenberg, K
    Lennéer-Axelson, B
    Samuelson, Gösta
    Strömbergson, LE
    Svenska barnfamiljer i glesbygd och stad: III. Varifrån får föräldrarna information om barn? Barnavårdscentralens roll.1982Conference paper (Other academic)
  • 82. Jonsell, R
    et al.
    Samuelson, Gösta
    "O-smakande" penicillin1978In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 75, no 37, p. 3165-3166Article in journal (Other academic)
  • 83. Jonsell, R
    et al.
    Samuelson, Gösta
    Sigurfinnsson, G P
    Haemophilus-cellulit och sepsis hos spädbarn - smittspridning troliga via syskon.[Haemophilus cellulitis and sepsis in infants--infection presumably spread via siblings].1980In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 77, no 8, p. 660-1Article in journal (Refereed)
  • 84. Jonsell, Ragnar
    et al.
    Samuelson, Gösta
    Winberg, Jan
    Kompendium i intravenös vätsketerapi för barn1974Book (Other academic)
  • 85. Lagerkvist, Bengt
    et al.
    Gustavsson, Karl-Henrik
    Samuelson, Gösta
    Kjellman, Bengt
    Lindberg, Tor
    Bedömning av godkändgräns vid flervalsprov i pediatrik1976In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 73, no 24, p. 2237-2239Article in journal (Other academic)
  • 86.
    Lantz, H
    et al.
    Sahlgrenska University Hospital, Department of Medicine.
    Brattby, L.-E
    Uppsala University Hospital, Department of Medical Sciences, Clinical Physiology.
    Fors, H.
    Northern Älvsborg Hospital, Trollhättan,Department of Paediatrics.
    Sandhagen, B.
    Uppsala University Hospital, Department of Medical Sciences, Clinical Physiology.
    Sjöström, L.
    Sahlgrenska University Hospital, Department of Medicine.
    Samuelson, Gösta
    University West, Department of Nursing, Health and Culture, Division of Advanced Nursing. University West, Department of Health Sciences, Section for nursing - graduate level.
    Body composition in a cohort of Swedish adolescents aged 15, 17 and 20.5 years2008In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 97, no 12, p. 1691-1697Article in journal (Refereed)
  • 87. Lantz, H
    et al.
    Samuelson, Gösta
    Bratteby, L E
    Mallmin, H
    Sjöström, L
    Differences in whole body measurements by DXA-scanning using two Lunar DPX-L machines1999In: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, ISSN 0307-0565, Vol. 23, no 7, p. 764-70Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To compare bone mineral and body composition results of two dual-energy X-ray absorptiometry (DXA) instruments from the same manufacturer.

    SETTINGS: The Medical departments of Sahlgrenska University Hospital, Göteborg and University Hospital, Uppsala, Sweden.

    DESIGN: Unique aluminium spine phantoms (Phant A and B) delivered with each DXA machine (DXA-A and DXA-B) were cross-checked on the other machine by using the 'AP spine mode'. Eight adolescents were examined on both instruments within 5 h to ascertain total body variables by using standard, as well as extended, modes of analysis. All these double-examinations were undertaken on two occasions, before and after exchange of a detector on the DXA-B.

    SUBJECTS: Four males and four females aged 15.4-19.2 y with normal body weights, were examined on both occasions. On each occasion, the first examination was performed in Göteborg on four individuals and in Uppsala on four individuals.

    RESULTS: On the first occasion the phantom measurements resulted in much lower bone mineral density (BMD) values on the DXA-B than on the DXA-A. Later it was detected that a so-called R-value and the corresponding '%-fat' value were out of range on the DXA-B. After exchange of detector, the difference in phantom BMD-values between the two machines had diminished. On the first occasion in vivo BMD values were lowest on the DXA-B (P < 0.01), while on the second occasion they were significantly lower on the DXA-A (P < 0.05). Soft tissue differences were greater after detector exchange and as compared to DXA-A, DXA-B underestimated body fat by 3.5 kg (13.2 vs 9.7 kg, P < 0.001) and overestimated lean tissue mass by 3.8 kg (47.1 vs 50.9 kg, P < 0.001) on the second occasion.

    CONCLUSIONS: The differences in results between two apparently identical Lunar DPX-L machines were not acceptable. In multicenter studies, it may be necessary to standardise results of participating machines into results of one machine by means of regression equations obtained by examining subsamples of individuals on one master machine and other participating instruments.

  • 88.
    Larsson, Ingrid
    et al.
    Department of Endocrinology, Diabetology and Metabolism, Internal medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg.
    Lissner, Lauren
    University of Gothenburg, Public Health Epidemiology Unit, Department of Public Health and Community Medicine, Sahlgrenska Academy, Gothenburg.
    Samuelson, Gösta
    University West, Department of Health Sciences, Specialist Nursing programme.
    Fors, Hans
    Department of Paediatrics, Northern Älvsborg Hospital, Trollhättan.
    Lantz, Henrik
    University of Gothenburg, Sahlgrenska University Hospital,Department of Endocrinology, Diabetology and Metabolism, Internal medicine, Gothenburg.
    Näslund, Ingmar
    Department of Surgery, Örebro University Hospital, Örebro.
    Carlsson, Lena M.
    Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg.
    Sjöström, Lars
    University of Gothenburg, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, .
    Bosaeus, Ingvar
    Department of Endocrinology, Diabetology and Metabolism, Internal medicine, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg.
    Body composition through adult life: Swedish reference data on body composition2015In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 69, no 7, p. 837-842Article in journal (Refereed)
    Abstract [en]

    Background/Objectives:The prevalence of obesity, defined as body mass index (BMI) greater than or equal to30 kg/m2, differs between populations; however, there is a need for data on description on body composition in reference populations of different ages and from different countries. The objective of this study was to pool dual-energy X-ray absorptiometry (DXA) body composition reference data from population-based Swedish cohorts.Subjects/Methods:Four population-based cross-sectional cohort studies including 1424 adult Swedes were divided into five age groups (20–29, 30–39, 40–49, 50–61 and 75 years of age); BMI 24.6±3.9 kg/m2 were pooled. Body composition was measured with DXA.

    Results:The difference in BMI from the youngest to the oldest age group was 3.2 and 4.3 kg/m2 in men and women, respectively (P<0.001, both sexes), and fat mass (FM) was 9.9 and 9.1% higher in the oldest compared with the youngest men and women (P<0.001, both sexes). Fat-free mass (FFM) remained stable up to 60 years of age in men (P=0.83) and was lower at 75 years of age compared with the younger ages. In women, FFM was lower from age 60. From youngest to oldest age groups, height-adjusted FM differed from 4.6 to 7.8 kg/m2 in men and from 6.8 to 10.8 kg/m2 in women (P<0.001, both sexes).

    Conclusions:Our results provide reference data on body composition in Swedish populations. BMI and FM were higher among older age groups compared with the younger ones. FFM remained stable up to 60 years of age and was lower first among the 75 years of age.

  • 89. Larsson, Y
    et al.
    Samuelson, Gösta
    Nytt vårdprogram för barn- och ungdomsdiabetes1988In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 85, no 4, p. 195-198Article in journal (Other academic)
  • 90. Larsson, Y
    et al.
    Samuelson, Gösta
    Tuvemo, T
    Åman, J
    Vårdprogram för barn- och ungdomsdiabetes1988In: XXII Nordiska Pediatriska kongressen, Reykjavik, 1988, 1988, no 4Conference paper (Other academic)
  • 91. Leonhardt, T
    et al.
    Samuelson, Gösta
    Spetz, S
    Erfarenheter av skötsel av gravida diabetiker vid ett länssjukhus: [Experiences of care of pregnant diabetics at a country hospital].1978In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 75, no 30-31, p. 2709-11Article in journal (Refereed)
  • 92. Lindberg, U
    et al.
    Bergström, AL
    Carlsson, E
    Dahlquist, G
    Hermansson, G
    Larsson, Y
    Nilsson, KO
    Samuelson, Gösta
    Sjöblad, S
    Thalme, B
    Urinary Tract Infection in Children with Type I Diabetes1985In: Acta pædiatrica Scandinavica, ISSN 0001-656X, Vol. 74, no 1, p. 85-88Article in journal (Other academic)
  • 93. Lindquist, B
    et al.
    Samuelson, Gösta
    Söderhjelm, L
    Wranne, L
    "Hälsokost" som barnmat1975In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 72, no 9, article id 820Article in journal (Other academic)
  • 94. Ludvigsson, J
    et al.
    Dahlqvist, G
    Edenvall, H
    Lundmark, KM
    Samuelson, Gösta
    Skogsberg, L
    Thilén, A
    Inskränkt aktiv extension av fingerleder hos juvenila diabetiker.1984Conference paper (Other academic)
  • 95. Lönnerdal, B
    et al.
    Samuelson, Gösta
    Järn, zink och selen i bröstmjölk: Vilken betydelse har mammans mat?2002In: Små & stora nyheter., ISSN 1400-4186, no 1, p. 4-5Article in journal (Other academic)
  • 96. Lötborn, M
    et al.
    Bratteby, L E
    Samuelson, Gösta
    Ljunghall, S
    Sjöström, L
    Whole-body bone mineral measurements in 15-year-old Swedish adolescents.1999In: Osteoporosis International, ISSN 0937-941X, E-ISSN 1433-2965, Vol. 9, no 2, p. 106-14Article in journal (Refereed)
    Abstract [en]

    Bone mineral area (BA), total bone mineral content (TBMC) and total bone mineral density (TBMD) were assessed by dual-energy X-ray absorptiometry (DXA) in 396 randomly selected, healthy 15-year-old Swedish boys and girls. The influence of body size, pubertal development, physical activity level (PAL), total energy expenditure (TEE), dietary intake of energy, calcium and vitamin D, and alcohol and smoking habits on TBMC and TBMD were examined in bi- and multivariate analyses. In bivariate analyses BA, TBMC and TBMD showed strong correlations with weight, height and TEE in both sexes. In boys but not in girls these bone variables were significantly correlated with dietary intakes of energy, calcium and vitamin D. No significant correlations were found between PAL and the three bone variables. In multivariate analyses with TBMC as dependent variable BA, height, weight and Tanner stages explained 88% and 87% of the variance in boys and girls respectively. In similar analyses with TBMD as dependent variable the corresponding figures were 50% and 54%. The major part of the variance in all these models was explained by BA, and only a few percent by all the other independent variables. No significant reduction was found when TEE or daily intakes of calcium or vitamin D were introduced into the models. These results illustrate the importance of including BA, weight and height as independent variables in regression models of TBMC to avoid spurious associations with other variables in the analyses. The results may also indicate that in normal Swedish adolescents environmental factors such as dietary intake of nutrients play a minor role as determinants of bone mineralization. High levels of physical activity and bone mineral measures possibly explain the lack of significant correlations between these variables and do not imply a lack of association.

  • 97. Maltau, J
    et al.
    Samuelson, Gösta
    Stakeberg, H
    Svedberg, S
    Ostergaard, E
    [Ammonia poisoning--experiences from an ice rink accident].1979In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 76, no 9, p. 723-4Article in journal (Refereed)
  • 98. Maltau, Jan
    et al.
    Samuelson, Gösta
    Stakeberg, Håkan
    Svedberg, Sven
    Östergaard, Erik
    Förgiftning med ammoniakgas: Erfarenheter från en isbaneolycka1979In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 76, no 9, p. 723-724Article in journal (Other academic)
  • 99. Melin, K
    et al.
    Samuelson, Gösta
    Gonadal dysgenesis with lymphocytic thyroiditis and deletion of the long arm of the X chromosome1969In: Acta paediatrica Scandinavica, ISSN 0001-656X, Vol. 58, no 6, p. 625-31Article in journal (Refereed)
  • 100. Michaelsen, K F
    et al.
    Johansen, J S
    Samuelson, Gösta
    Price, P A
    Christiansen, C
    Serum bone gamma-carboxyglutamic acid protein in a longitudinal study of infants: lower values in formula-fed infants.1992In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 31, no 4 Pt 1, p. 401-5Article in journal (Refereed)
    Abstract [en]

    Bone gamma-carboxyglutamic acid protein [BGP (osteocalcin)] is a protein synthesized by osteoblasts and incorporated in the bone matrix. Serum BGP is a sensitive marker of bone formation, and it parallels the growth velocity curve during childhood and adolescence. Serum BGP was measured at the age of 2, 6, and 9 mo in a cohort study of nutrition and growth in 91 healthy infants. At 2 mo, the mean BGP value (+/- SD) was 275 +/- 87 ng/mL in infants exclusively breast-fed, and 80 +/- 44 ng/mL in formula-fed infants. At 6 mo, the values were 142 +/- 58 ng/mL and 55 +/- 30 ng/mL, and at 9 mo 75 +/- 39 ng/mL and 45 +/- 19 ng/mL in partially breast-fed and formula-fed infants, respectively. The differences were significant (p less than 0.001) at all three ages. At 2 and 9 mo, breast-milk intake was measured by test-weighing. Serum BGP was positively correlated to breast milk intake (mL/kg body wt) at 2 mo (r = 0.59, p less than 0.001) and 9 mo (r = 0.41, p = 0.06). When breast-feeding was stopped, the high BGP concentrations were not sustained. There were no significant differences in linear growth velocity between breast-fed and formula-fed infants and no correlation between BGP values and linear growth velocity. We speculate that either a factor in human milk or the level of minerals in human milk causes the high BGP values. Moreover, if the higher values are associated with increased osteoblast activity, then the remodeling or the mineralization of bone might be different in infants not being breast-fed.

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