Background:. Anorexia nervosa (AN) is a complex disease that is increasing in society. Often the person who suffers from anorexia nervosa has no medical insight and is opposed to the treatment and care. It takes many resources from the nurses to try to get the patient to experience better health. Previous research has limitations on how nurses feel that caring for patients suffering from AN and to be able to have a care of good quality more knowledge about the current topic is needed.Aim: The purpose of this study was to elucidate registered nurses' experience of caring for patients suffering from anorexia nervosaMethod: The study was based on to Friberg's (2012) qualitative content analyse for literature based studies. Five qualitative articles were used in this study, to get a deeper knowledge about this topic.Results: The analysis revealed two categories and four subcategories: creating a relationship and an ongoing struggle. The nurses' role is to create the quality of the meeting between her and her patient. The nurse should see the individual behind the disease and patients respond equally. This is not always easy when patients suffering with AN often sabotages and manipulate, because they do not see the seriousness of AN. This becomes a frustration for the nurse, when they feel they cannot help their patient.Conclusion: Nurses find it tough to meet her patients with anorexia nervosa. They felt failed when they could not help their patients. As future nurses need more knowledge and education.