The main challenge in producing aerospace components using Ti-6Al-4V alloy is to employ the optimum process window of deformation rate and temperature in order to achieve desired material properties. Understanding the microstructure property relationship qualitatively is not enough to achieve this goal. Developing advanced material models to be used in manufacturing process simulation is the key to iteratively computeand optimize the process. The focus in this work is on physically based flow stress models coupled with microstructure evolution models. Such a model can be used to simulate processes involving complex and cyclic thermo-mechanical loading