Background: In Namibia, the infectious lung disease Tuberculosis is still a major public health threat. The Registered Nurses play an important role in educating and informing both the patients but also their relatives and the general public.

Aim: This study aims to describe the experiences of Registered Nurses in Namibia and how they consider the care given to patients with Tuberculosis including their beliefs of which factors that could affect the patients' health and adherence to treatment.

Method: Six qualitative semi structured interviews were conducted with six registered nurses at the Tuberculosis unit at a public State Hospital in Namibia. All collected data was analyzed through a qualitative content analysis.

Results: The result consists of one overall theme, three main themes, and eight underlying themes. The overall theme is; Managing Tuberculosis care - an uphill struggle, the three main themes are; Challenges for the nurse, Patient related challenges and Challenges for society.

Conclusion: The result showed that the Registered Nurses found it important to provide quality in the care relationship and to educate patients to promote health and adherence. This was important since the patients with tuberculosis faced a lot of difficulties related to the disease; like social exclusion, other difficult side effects and the struggle with poverty. Substance dependence was another factor associated with poverty which further problematized the caring process. Lack of experienced Registered Nurses and lack of beds in the hospital were also perceived challenges