Background: By experiencing pain, children can recall to the situation and the pain can have a negative effect in the future. Painful procedures constitute a major part of the experience that children have of pain. Children cannot understand the benefits of the painful procedure based on their level of development neither that the procedure may be important for their health. Aim: The aim of this study was to describe different nursing interventions to prevent and alleviate children's procedural pain, anxiety and fear associated with peripheral venipuncture in children (aged 2-12 years). Method: This study was designed as a literature review and 10 articles, which corresponded to the aim of the study, were analyzed. Results: The results showed that distraction, support, and information can facilitate peripheral venipuncture for children. Various distraction techniques can be used to relieve children's pain, anxiety and fear during venipuncture. Examples of distraction methods is blowing soap bubbles, looking in a kaleidoscope or watching television. Nurses' positive approach can lead to successful procedure. Closeness of a parent during venipuncture can have a positive effect for the child while information is the key to a good relationship between nurse, parent and a child. Conclusion: Using distraction methods associated with peripheral venipuncture is a practical tool for children independent of age and development to relieve and prevent pain, anxiety and fear. Parental participation creates the ability to motivate the child to implement a peripheral venipuncture. A nurse can facilitate the peripheral venipuncture by supporting and informing the child with humor and the use of a simple language.