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Nedsatt serotoninhalt predisponerar för våld: Enkelt blodprov förutsäger farlighet
(Karolinska Institutet)
Karolinska Institutet.ORCID iD: 0000-0002-8562-5610
1997 (Swedish)In: Läkartidningen, ISSN 0023-7205, Vol. 94, no 39, 3385-3388 p.Article in journal (Refereed) Published
Abstract [en]

Deficient serotonergic function in the brain is associated with a risk of impulsive violence. The level of serotonergic function can be assessed indirectly in several ways: 1. determination of CSF (cerebrospinal fluid) content of the serotonin metabolite 5-HIAA (5-hydroxyindoleacetic acid); 2. determination of the plasma level of the amino acid tryptophan, the serotonin precursor (passage of tryptophan into the brain is dependent on the ratio of tryptophan to other competing amino acids); 3. analysis of platelet monoamine oxidase content, a putative correlate of serotonergic capacity in the brain; 4. by determining response to an OGTT (oral glucose tolerance test), another putative correlate of serotonergic function.

Abstract [sv]

En nedsatt serotonerg funktion har visat sig vara förenad med impulsivt destruktivt beteende, såsom mord, anstiftan till mordbrand och våldsamma självmord. Halten av monoaminoxidas (MAO) är kopplad till hjärnans serotonerga kapacitet, och är av central betydelse för att förutsäga farlighet. Genom ett enkelt blodprov kan MAO-halten i trombocyter mätas, en undersökning som bör ingå i varje rättspsykiatrisk undersökning.

Place, publisher, year, edition, pages
Stockholm, 1997. Vol. 94, no 39, 3385-3388 p.
Keyword [en]
5 hydroxyindoleacetic acid, serotonin, tryptophan, blood sample, cerebrospinal fluid, emotion, glucose tolerance test, metabolism, violence
Keyword [sv]
5-hydroxindolättiksyra, serotonin, tryptofan, blodprov, likvor, emotioner, blodsockerbelastning, metabolism, våld
National Category
Social and Clinical Pharmacy Psychiatry
Research subject
SOCIAL SCIENCE, Psychology
Identifiers
URN: urn:nbn:se:hv:diva-5036OAI: oai:DiVA.org:hv-5036DiVA: diva2:585342
Note

Engelsk titel;

Deficient serotonergic function is predisposing to violence, the risk is predictable with a simple test

Available from: 2013-01-10 Created: 2013-01-10 Last updated: 2015-02-03Bibliographically approved

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