The focus of this section is on mental health in a life course perspective and cultural aspects on the Sense of Coherence. According to Aaron Antonovsky the key concept, the Sense of Coherence (SOC),was considered as a universal construct measuring a global life orientation, away of viewing the life as comprehensible, manageable and meaningful. The conclusions drawn in this section is based on an extensive systematic research synthesis of papers on salutogenesis  covering the time span 1992-2003 and published in 2007, completed with an ongoing work of additional papers up to 2010. The cultural aspects of the SOC are reflectedby using ethnic minorities as examples of groups affected by acculturative stress? The distribution of the SOC questionnaire is described?  The results showed that a strong SOC is related to good perceived mental health and well-being independent of age. Further, the SOC questionnaire has to date beenused in different countries on various languages all over the World, not onlyin Western countries. The proposed universal property of the SOC is questioned. The SOC seems to be influenced by culture. Further research is needed to get adeeper understanding how the SOC operates in different cultural contexts.