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Enhanced feminine sexual behavior and infertility in female rats prenatally treated with an antiestrogen
University West, Department of Social and Behavioural Studies, Division of Psychology and Organisation Studies.
2003 (English)In: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 44, no 3, p. 251-6Article in journal (Refereed) Published
Abstract [en]

An attempt to elucidate the possible role of prenatal estrogen on the development of feminine sexual behavior and reproductive function was made by treating females with the antiestrogen CI628 prenatally on days 13-19. Control females were prenatally treated with saline or remained untreated. The animals were delivered by caesarian section on day 22 of pregnancy and placed with foster mothers whose newborn pups had been previously removed. Intact peripubertal females in each treatment group were observed for several reproductive measures, including the capacity to become pregnant. Other females were ovariectomized in adulthood and treated with estradiol benzoate (EB) (1, 1.5, 2 or 4 micro g/rat) and 0.5 mg progesterone and tested for receptivity, proceptivity and sexual partner preference. Two weeks after the completion of these tests, the females were injected daily for 7 days with 0.25 mg testosterone and tested for sexual partner preference and mounting behavior. The results obtained showed accelerated vaginal opening, and infertility in the antiestrogen-treated intact females and enhanced receptivity and proceptivity in response to 1 micro g EB in the antiestrogen ovariectomized females. Sexual partner preference and mounting behavior did not differ between groups. These results suggest an involvement of prenatal estrogen on the development of female reproductive function, but not on behavioral differentiation.

Place, publisher, year, edition, pages
2003. Vol. 44, no 3, p. 251-6
Keywords [en]
Prenatal estrogen, prenatal antiestrogen, female development, masculine and feminine sexual behavior, fertility
National Category
Psychology
Research subject
Social science, Psychology
Identifiers
URN: urn:nbn:se:hv:diva-1761DOI: 10.1111/1467-9450.00342PubMedID: 12914588OAI: oai:DiVA.org:hv-1761DiVA, id: diva2:241985
Available from: 2009-10-06 Created: 2009-10-02 Last updated: 2017-12-13Bibliographically approved

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CiteExportLink to record
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