Background: Palliative care has evolved from the origins of relieving and managing symptoms in cancer patients, to a holistic philosophy that aims to enhance the quality of life for everyone facing life-threatening illnesses. This means nurses must be able to take care of and recognize the physical, psychological, social and spiritual needs of patients through symptom relief, communication, teamwork and support. Research shows that nurses who work with palliative care experience moral distress due to the lack of time and high workload facing them with ethical dilemmas. Aim: The aim of this study was to describe nurses’ experiences of working with palliative care towards adults at the end-of-life. Method: A literature-based qualitative study was conducted using seven scientific articles related to the experiences of nurses working in palliative care. Results: Two main themes emerged consisting of four subthemes. Learning from each other is expressed through Evolving through experience and Communication and collaboration. Second main theme: Caring for oneself explained through The importance of recovery and Promoting a safe work environment. Conclusion: Palliative care is an emotionally challenging form of care filled with complexity. Although nurses identified that collegial support, effective communication, self-care practices and a safe work environment were beneficial, there remains room for improvement in these areas.