Processing of high-performance materials by laser beam powder bed fusion (LB-PBF) provides an alternative manufacturing route to, i.e., investment casting and is suitable for production of high-performance materials having complex geometry such as turbine blades. The main benefit of powder bed fusion in general is associated with the fact that increased geometrical complexity does not add any cost. However, the processability of the alloys of interest is closely linked to process parameters where highperformance materials belong to a special class of materials that need substantial attention to avoid problems, not at least with regard to different types of cracking. In this chapter, the relationship between process parameter-microstructure-defect relationship will be discussed and analyzed.