Background: To work in Palliative Care can be difficult and challenging for nurses, in which they meet existential issues concerning life and death. This requires nurses to meet the patient's relatives to discuss these issues. Nurses have the responsibility to invite patients and their relatives to converse about existential issues.

Aim: To describe the nurse’s experience of existential conversation with both patients at the end of life and their relatives.

Method: The study was based on a qualitative literature study with ten scientific articles. The articles were searched from databases Cinahl and PubMed. Friberg’s five-step model was used to analyze the articles.

Results: Through the analyses, three major themes were formed: The experience of communication in existential conversation described meaningful and important to be attentive and active listening. The experience of vulnerability described the feeling of fear, anxiety and despair and the feeling of inadequacy and powerlessness. The experience of factors that influence existential conservation that described the lack of time and own experience and experienced colleagues who provide better conditions to perform the conversations.

Conclusion: Nurses experienced different emotions while providing an existential conversation. Conservation about existential needs to alleviate the patients and their relatives' suffering experienced as meaningful. While the feeling of inadequacy and powerlessness to alleviate the patient’s suffering and the feeling of fear, anxiety and despair about their own death and life created negative emotions in nurses that lead them to feel more vulnerable.