Blockchain is one of the latest innovations that is increasingly attracting the attention of various stakeholders in different fields, including the education sector. This is primarily due to its attractive features, such as decentralization, transparency, traceability, security, and reliability. Despite its advantages, blockchain still faces several challenges, and the acceptance rate of this technology is still low. Thus, the purpose of this study was to conduct a review of published articles that have discussed the challenges of adopting blockchain in the education sector. The review contained scientific papers published from 2017 to 2022 and, from the screened records, 32 articles were analyzed in full-text form. In this review, 14 challenges were reported and classified, based on the technology-organization-environment (TOE) framework. In addition, this review showed that organizational and environmental barriers received little attention in the literature, compared to technological barriers. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.