The present study provides a literature review on the adolescent’s competence to consent to healthcare decisions. Following an interdisciplinary approach, the notion of adolescent’s competence is explored through developmental, neuroscientific, legal, cultural and rights perspectives. My findings demonstrate that the concept of adolescent competence to consent is complicated, as it is influenced and shaped by a variety of factors. My findings provide information and research evidence to healthcare providers and policy-makers pertaining adolescent’s competence to consent to medical decisions.