The transition from student to nursing profession can be experienced as both challenging and frightening. Stress is a common feeling that newly graduated nurses experience in the beginning of their career. The new role as registered nurse is knowledge-intensive and entails increased responsibility for others. Difficult and unexpected situations can arise and can be difficult to handle, with stress and uncertainty as a result. In the worst case, a care injury can occur because patient safety is endangered. The aim of this study was to describe work-related stress in newly graduated nurses. The research method was a litterateur review based on qualitative and quantitative articles. Friberg’s three-step model were used to analyze the articles. The analysis resulted in three themes and six subthemes. The first theme was Feeling unprepared which described lack of knowledge and skills, lack of self-confidence. The second theme was Workload which described understaffed and time pressure, fatigue and stress. The third theme was Loneliness which described horizontal violence, lack of support and encouragement. The results of this study show that newly graduated nurses experience the transition from student to registered nurse as stressful. They experience difficulties during the first period of their career, where they face several problems. Continuous help and support should be available for newly graduated nurses in order to contribute to professional development and improve clinical learning.