Background: Work-related stressors is a global issue that should have more awareness to prevent serious health consequences. This study dives into the subject of chronic stress; such as work-related stress that can cause fatigue syndrome. It is about how these stress factors can concern a registered nurse ability to work with patients’ safety and the effect of the nurses’ health.

Aim: The aim of the study was to identify work-related stressors of a registered nurse and its consequences.

Method: This study is based on an analysis of qualitative research that contributes to evidence-based health care (EBHC). The method is literature based and utilizes scientific articles about the nurses profession and their own personal experiences.

Results: There were three different themes that contributed to work-related stress factors and they are crucial to the nurse's role. These factors increase the difficulty of practicing the profession and there are explanations of how it affects the individual nurse mentally and physically.

Conclusion: The study indicates that the profession as a nurse is wearisome and the most significant stress factor in this study is the high workload. Nurses are forced to work under pressure in conjunction with lack of resources and lack of time. This type of factor affects the nurses health.