This thesis presents a dynamic Human Machine Interface (HMI), designed for use in a Plug & Produce system. The HMI adapts depending on available resources and their signals. APlug & Produce demonstrator, which is referred to as the SMART Cell throughout the project, is used for testing the designed HMI. This demonstrator is reconfigurable in its core. It encases several positions where process modules can be attached, disconnected, or switch places at any time, depending on the needs of production. A system with these characteristics and structure is a viable solution for the production challenges of the future industry. Thus, a dynamic HMI to represent and control the manufacturing system without the need of being reprogrammed each time the system changes is deemed necessary. The solution is using a web-based approach, where a database acts as the communication channel between the HMI and the connected resources. Adapters can be developed for connecting resources to this database using almost any industrial communication protocol. A computer in the SMART Cell takes the role of a server while the HMI, projected in a small tablet computer, is the client, where the operators can interact with it. Testing the proposed solution has shown that the designed HMI can automatically adapt to the available signals given by connected resources. The HMI is also adapting to the current operator, based on several profiles created with different characteristics in the HMI layout.