Background: Venipuncture is one of the most painful procedures that a child goes through in the medical care which creates both pain, anxiety and fear. Non-pharmacological interventions are not used enough to alleviate the children's suffering. This is why it is important for the nurse to be aware of which non-pharmacological intervention that is effective to practice during venipuncture.

Aim: The aim of the study was to describe how the nurse can alleviate pain, anxiety and fear by using non-pharmacological interventions in children ages 0-12 years during venipuncture.

Method: A literature review was cunducted based on both quantitative and qualitative research. Eighteen articles were analysed and critically reviewed.

Results: The results revealed two main themes supportive interventions during venipuncture and distraction interventions during venipuncture following five subthemes. The result showed that the nurse can alleviate pain, anxiety and fear in children during venipuncture by an age-appropriate information, play with the child and use different methods to make the child feel secure. The result also showed that the nurse can use both active and passive distraction to alleviate pain, anxiety and fear in children during venipuncture.

Conclusion: The main finding was that the nurse should use both supportive interventions to create security and distraction which is an effective method to reduce pain, anxiety and fear through making the child focus on something else than the venipuncture. It is important that the non-pharmacological interventions are adapted according to each child's needs.