Varestraint weldability testing and Gleeble thermomechanical simulation of the newly developed cast form of Haynes® 282® were performed to understand how heat-affected-zone (HAZ) liquation cracking is influenced by different preweld heat treatments. In contrast to common understanding, cracking susceptibility did not improve with a higher degree of homogenization achieved at a higher heat-treatment temperature. Heat treatments with a 4 h dwell time at 1120 °C and 1160 °C exhibited low cracking sensitivity, whereas by increasing the temperature to 1190 °C, the cracking was exacerbated. Nanosecond ion mass spectrometry analysis was done to characterize B segregation at grain boundaries that the 1190 °C heat treatment indicated to be liberated from the dissolution of C–B rich precipitates