This study addresses the issue of knowledge management. The results are based on field study of a quality support group in a pharmaceutical company. Particularly,the knowledge work activities are analysed in a framework of a knowledge management process and its possibilities for IT-support. From the results I can conclude that mainly explicit knowledge is managed in this process. However, the specific use of two knowledge-mediating systems seems to be extremely important("the very lifeline") throughout this knowledge management process. Knowledge can be transferable and distributed electronically among dispersed co-workers,adaptable and tailor-made to the needs of different users, and applicable directly to practitioners. In a discussion of a more general IT-based knowledge management process I go beyond the specific use of these knowledge-mediating systems and try to identify some further needs and requirements