Despite the industrial relevance of LASER welding, determination of sustainable parameterization is still a challenge. Trial and error, or even not totally justified methodologies, are frequently applied on LASER welding parametrization. This approach potentially leads to a decrease of the process tolerance and, consequently, increasing the likelihood of imperfections, which means extra operational time and raising of the final cost. The present paper addresses a comparative discussion about five factors experimentally determined and frequently used to predict depth of penetration in LASER welding. The experiments were performed with a 10-kW fiber LASER. In a first batch, power was varied while welding speed was fixed at 1 m/min. In a second batch, welding speed was varied and power was kept at 10 kW. The first demonstrated concern on using these popular factors is the definition and quantification of LASER energy. For evidencing this aspect, two samples were processed with the same welding energy of 120 kJ/m, yet resulting in completely different penetrations. Eventually, an empirical model based on power as a factor allowed a more reliable prediction of the depth of penetration.