Background: Osteoarthrosis is considered the 11th most common disorder that causes the greatest disability and gradually decline the patient’s quality of life. Studies have shown that 80% of the patients have different types of disabilities and 25% can not perform their daily activities. Aim: The purpose of this study was to describe patients’ experiences of being stricken with knee osteoarthritis. Method: A literature-based study was chosen as the method that conduce to evidence-based nursing by analyzing qualitative research. The analysis resulted in three main themes and seven subthemes. Results: Three main themes were: “Daily challenges”, “To relieve symptoms” and “To be cared”. The main finding was that knee osteoarthritis considered to be the central focus in the patients’ lives which caused physical and socio-economies limitations. This worsened their quality of life and mental well-being. Although surgery considered to be the only solution, the expectations regarding the outcome differed. Conclusion: It is important to treat knee osteoarthritis in early course of the disease to prevent limitations and other diseases. The patient’s need information and support to manage their symptoms.