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Microporous Hydroxyapatite Ceramic Composites as Tissue Engineering Scaffolds: An Experimental and Computational Study
Biomaterials Processing and Characterization Laboratory Department of Materials Science and Engineering Indian Institute of Technology Kanpur Kanpur-208016, Uttar Pradesh, India.
Biomaterials Processing and Characterization Laboratory Department of Materials Science and Engineering Indian Institute of Technology Kanpur Kanpur-208016, Uttar Pradesh, India.
Department of Textile Technology Indian Institute of Technology Delhi New Delhi, 110016, India.
Biomaterials Processing and Characterization Laboratory Department of Materials Science and Engineering Indian Institute of Technology Kanpur Kanpur-208016, Uttar Pradesh, India.
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2018 (English)In: Advanced Engineering Materials, ISSN 1438-1656, E-ISSN 1527-2648Article in journal (Refereed) Epub ahead of print
Abstract [en]

Bone‐tissue engineering mandates the development of multi‐functional bioactive porous hydroxyapatite (HAp) scaffolds. Herein, microwave sintered HAp/ZnO and HAp/Ag composite scaffolds with ≈5–19% porosity are developed using 0–30 vol% graphite as a porogen. The mechanical properties of the porous scaffold are analyzed in detail, revealing that even being more porous, the reinforcement of ZnO (9% porosity, hardness of 2.8 GPa, and toughness of 3.5 MPa.m1/2) has shown to have better hardness and fracture toughness when compared to Ag (5% porosity, hardness of 1.6 GPa, and toughness of 2.6 MPa.m1/2). The flexural strength obtained experimentally are complemented with a finite‐element technique that adopts microstructural features in visualizing the effect of porosity on stress distribution. The antibacterial efficacy and cytocompatibility of these composites are validated by increased metabolic activity and conspicuous cell‐matrix interactions. The anticipation of the results reveal that HAp/ZnO (9% porosity) and HAp/Ag (5% porosity) composites can be used as a potential multi‐functional bone implant scaffolds.

Place, publisher, year, edition, pages
2018.
Keyword [en]
Antibacterial, Cytocompatibility, Diametrical Compression Test, Hydroxyapatite, Object‐Oriented Finite Element Modeling (OOF2), Porosity, Silver, Zinc Oxide
National Category
Manufacturing, Surface and Joining Technology Biomaterials Science Metallurgy and Metallic Materials
Research subject
ENGINEERING, Manufacturing and materials engineering
Identifiers
URN: urn:nbn:se:hv:diva-12249DOI: 10.1002/adem.201701062OAI: oai:DiVA.org:hv-12249DiVA, id: diva2:1196498
Available from: 2018-04-10 Created: 2018-04-10 Last updated: 2018-04-10Bibliographically approved

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Goel, Sneha

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