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Determination of age- and sex-specific 99th percentiles for high-sensitive troponin T from patients: An analytical imprecision- and partitioning-based approach
Department of Metabolic Biochemistry, La Pitié Salpêtrière-Charles Foix University Hospital, Paris, France.
University West, School of Business, Economics and IT, Divison of Informatics. Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Scandinavian Surgical Outcomes Research Group, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID iD: 0000-0002-0575-4309
Paris Descartes University, Faculty of Pharmacy, Department of Biochemistry, Paris, France.
2018 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, E-ISSN 1437-4331, Vol. 56, no 5, p. 818-829Article in journal (Other academic) Published
Abstract [en]

Detection of acute myocardial infarction (AMI) is mainly based on a rise of cardiac troponin with at least one value above the 99th percentile upper reference limit (99th URL). However, circulating high-sensitive cardiac troponin T (hs-cTnT) concentrations depend on age, sex and renal function. Using an analytical imprecision-based approach, we aimed to determine age- A nd sex-specific hs-cTnT 99th URLs for patients without chronic kidney disease (CKD). A 3.8-year retrospective analysis of a hospital laboratory database allowed the selection of adult patients with concomitant plasma hs-cTnT (<300 ng/L) and creatinine concentrations, both assayed twice within 72 h with at least 3 h between measurements. Absence of AMI was assumed when the variation between serial hs-cTnT values was below the adjusted-analytical change limit calculated according to the inverse polynomial regression of analytical imprecision. Specific URLs were determined using Clinical and Laboratory Standards Institute (CLSI) methods, and partitioning was tested using the proportion method, after adjustment for unequal prevalences. After outlier removal (men: 8.7%; women: 6.6%), 1414 men and 1082 women with estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 were assumed as non-AMI. Partitioning into age groups of 18-50, 51-70 and 71-98 years, the hs-cTnT 99th URLs adjusted on French prevalence were 18, 33, 66 and 16, 30, 84 ng/L for men and women, respectively. Age-partitioning was clearly required. However, sex-partitioning was not justified for subjects aged 18-50 and 51-70 years for whom a common hs-cTnT 99th URLs of about 17 and 31 ng/L could be used. Based on a laboratory approach, this study supports the need for age-specific hs-cTnT 99th URLs. © 2017 Walter de Gruyter GmbH.

Place, publisher, year, edition, pages
Walter de Gruyter GmbH , 2018. Vol. 56, no 5, p. 818-829
National Category
Cardiac and Cardiovascular Systems
Research subject
SOCIAL SCIENCE, Informatics
Identifiers
URN: urn:nbn:se:hv:diva-11984DOI: 10.1515/cclm-2017-0256ISI: 000429037600023Scopus ID: 2-s2.0-85037822423OAI: oai:DiVA.org:hv-11984DiVA, id: diva2:1174665
Note

Published Online: 2017-11-25

Available from: 2018-01-16 Created: 2018-01-16 Last updated: 2018-04-26Bibliographically approved

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