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Innovative intraoral cooling device better tolerated and equally effective as ice cooling.
University of Gothenburg, Department of Oral Medicine & Pathology, Institute of Odontology, The Sahlgrenska Academy, Box 450, 405 30, Gothenburg, Sweden.
University West, School of Business, Economics and IT, Divison of Law, Economics, Statistics and Politics. University West, School of Business, Economics and IT, Divison of Informatics.ORCID iD: 0000-0002-0575-4309
Uppsala University,Department of Hematology, Institute for Medical Sciences, Faculty of Medicine, Uppsala University Hospital, 751 85, Uppsala, Sweden.
University of Gothenburg, Department of Oral Medicine & Pathology, Institute of Odontology, The Sahlgrenska Academy, Box 450, 405 30, Gothenburg, Sweden..
2017 (English)In: Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, E-ISSN 1432-0843, Vol. 80, no 5, 965-972 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Most of the patients who receive myeloablative therapy prior to stem cell transplantation develop oral mucositis (OM). This adverse reaction manifests as oral mucosal erythema and ulcerations and may require high doses of morphine for pain alleviation. OM may also interfere with food intake and result in weight loss, a need for parenteral nutrition, and impaired quality of life. To date, there have been very few studies of evidence-based interventions for the prevention of OM. Cryotherapy, using ice chips, has been shown to reduce in an efficient manner the severity and extent of OM, although clinical applications are still limited due to several shortcomings, such as adverse tooth sensations, problems with infectious organisms in the water, nausea, and uneven cooling of the oral mucosa. The present proof-of-concept study was conducted to compare the tolerability, temperature reduction, and cooling distribution profiles of an intra-oral cooling device and ice chips in healthy volunteers who did not receive myeloablative treatment, and therefore, did not experience the symptoms of OM.

METHODS: Twenty healthy volunteers used the cooling device and ice chips for a maximum of 60 min each, using a cross-over design. The baseline and final temperatures were measured at eight intra-oral locations using an infra-red thermographic camera. The thermographic images were analysed using two digital software packages. A questionnaire was used to assess the tolerability levels of the two interventions.

RESULTS: The intra-oral cooling device was significantly better tolerated than the ice-chips (p = 0.0118). The two interventions were equally effective regarding temperature reduction and cooling distribution.

CONCLUSIONS: The intra-oral cooling device shows superior tolerability in healthy volunteers. Furthermore, this study shows that temperature reduction and cooling distribution are achieved equally well using either method.

Place, publisher, year, edition, pages
2017. Vol. 80, no 5, 965-972 p.
Keyword [en]
Cryotherapy, Healthy volunteers, Intra-oral cooling device, Myeloablative therapy, Oral mucositis, Tolerability
National Category
Pharmaceutical Sciences Cancer and Oncology
Research subject
SOCIAL SCIENCE, Informatics
Identifiers
URN: urn:nbn:se:hv:diva-11806DOI: 10.1007/s00280-017-3434-2ISI: 000414762300009PubMedID: 28975429Scopus ID: 2-s2.0-85030321787OAI: oai:DiVA.org:hv-11806DiVA: diva2:1159583
Note

First Online: 03 October 2017

Available from: 2017-11-23 Created: 2017-11-23 Last updated: 2017-12-11Bibliographically approved

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Gellerstedt, Martin

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