Background: Depression after childbirth affects more than one out of ten new mothers and could have a negative impact on the baby´s development. In Sweden every mother is screened for postpartum depression when the baby is six to eight weeks. Aim: The aim of this study was to examine nurses’ experiences of depression in new mothers. Method: The study was based on ten semi-structured interviews with nurses at a child care centre. The data were analyzed using qualitative content analysis with an inductive approach. Results: Two categories and seven subcategories appeared from the analysis. Nurses described that it was important to see early signs. Early signs that worried could include breastfeeding, sleeping discomfort and crying. The nurses also observed the connection between the mother and the child and they analyzed the situation. The nurses also described the importance of support to the parents. This was done by building a good relationship and providing information, offering supportive dialogues, co-operation across professional borders and support by their families’ involvement. Having a plan to take care of the mothers gave safety to the nurse. Nurses felt that the cooperation across the professions worked well. They were supervised by psychologists every two three or four weeks. The family´s involvement was important for the mothers described the nurses. Most mothers had good support in their partner. The support of grandparents to the child was also important. Conclusion: The red thread through our work is communication. It requires good communication with the mothers, including a genuine interest in listening and understanding the mothers’ experiences and feelings. In order to provide good care to the new mothers there is also a need for good communication between the professionals during the caring process.