Aims and objectives: To describe District nurses' experiences working with asylum-seeking families in childcare centers.  Background: The number of people seeking asylum in Sweden has increased during the past years and reached it' s peak in 2015 when a total of 163.000 asylum-seekers arrived in the country. The situation meant an increased strain on the Swedish healthcare system partly due to the law-regulated right of all children to receive equal healthcare. Previous studies have shown that refugee-children is a vulnerable group often with an increased need of healthcare. Studies has also shown that offering healthcare to people of different cultural and national heritage than your own can be demanding. Design: A qualitative study using semi-structured interviews and content analysis. The study is a part of the examination work of the District nursing program at West University of Sweden.  Methods: 10 District nurses in the region of Västra Götaland in the western part of Sweden completed individual interviews and the data were analyzed using content analysis.  Results: The data-analysis identified four main categories: The individual needs of the asylum-seeking family, flexible work, communicative challenges and cultural challenges.  Conclusion: The District nurses found the increase and changes of their working situation to be demanding. Adapting to language, - and cultural differences were resource consuming and the ability to work healthpromoting with the asylum-seeking families were challenging due to their strained life situation. In order to cope became the feeling of meaningfulness in the job-assignment and ability to have flexibility and familyorientated approach in their work crucial. District nurses' work with these families must be studied in greater depth to identify the changes in the present asylum-situation and further locate areas within the District nurses' work in need of improvement to secure the care of this vulnerable group.