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Porosity distribution affecting mechanical and biological behaviour of hydroxyapatite bioceramic composites
Laboratory for Biomaterials, Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India.
Laboratory for Biomaterials, Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India.
University West, Department of Engineering Science, Division of Subtractive and Additive Manufacturing. (PTW)ORCID iD: 0000-0001-5676-7903
Laboratory for Biomaterials, Department of Materials Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, 208016, Uttar Pradesh, India.
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2017 (English)In: Ceramics International, ISSN 0272-8842, E-ISSN 1873-3956, Vol. 43, no 13, p. 10442-10449Article in journal (Refereed) Published
Abstract [en]

The present work aims to the study of developing porosity in hydroxyapatite (HAp) scaffold by using graphite porogen (with 0-30 vol%) followed by engineering the changes achieved by conventional- (CS) and microwave sintering (MS) techniques. The generated porosity was controlled between similar to 6-27% as the porogen concentration increases in HAp scaffold. Voronoi tessellation was utilized in order to evaluate the distribution of pores. The enhanced mechanical properties including fracture toughness (0.83 MPa m(1/2)), fracture strength (7.5 MPa), and hardness (183.7 VHN) were observed for microwave sintered HAp scaffold with 8% porosity. The fitting between porosity and fracture strength elicited that microwave sintered HAp with 8% porosity provides maximum crack-propagation resistance while restricting grain size (similar to 0.23 mu m) and eliciting high extent of sintering (similar to 1.34) because of their rapid heating rates. The cell viability (MTT assay) and cell culture confirm the cytocompatibility of porous HAp for application as bone implant that need accelerated replacement of bone tissues.

Place, publisher, year, edition, pages
2017. Vol. 43, no 13, p. 10442-10449
Keywords [en]
Hydroxyapatite; Porosity; Voronoi tessellation; Mechanical property; Cytocompatibility
National Category
Manufacturing, Surface and Joining Technology
Research subject
ENGINEERING, Manufacturing and materials engineering
Identifiers
URN: urn:nbn:se:hv:diva-11398DOI: 10.1016/j.ceramint.2017.05.083ISI: 000406438700111Scopus ID: 2-s2.0-85020135751OAI: oai:DiVA.org:hv-11398DiVA, id: diva2:1136192
Note

Funders: Ministry of Human Rersource Development, Government  of India

Available from: 2017-08-25 Created: 2017-08-25 Last updated: 2019-05-23Bibliographically approved

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Goel, Sneha

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