The ongoing trend towards manufacturing of customized products generates an increased demand on highly efficient work methods to manage product variants through flexible automation. Adopting robots for automation is not always feasible in low batch production. However, the combination of humans together with robots performing tasks in collaboration provides a complementary mix of skill and creativity of humans, and precision and strength of robots which support flexible production in small series down to one-off production. Through this, collaboration can be used with implications on reconfiguration and production. In this paper, the focus and study is on designing safety for efficient collaboration operator—robot in selected work task scenarios. The recently published ISO/TS 15066:2016 describing collaboration between operator and robot is in this context an important document for development and implementation of robotic systems designed for collaboration between operator and robot.