Processing of high-performance materials by Directed Energy Deposition with Powders (L-DED-P) is frequently utilized in repair as well as remanufacturing apart from manufacturing. One benefit of the process is the low heat input in comparison to, i.e., L-DED with wire which is preferable regarding residual stresses and distortion. However, care must be taken to minimize defects that are at stake in forming if process parameters are not adequately adapted to the specific application. There is a strong correlation between the process parameters and metallurgical behavior which in turn give rise to potential defects and the final performance of the part to be produced. This chapter gives an overview of the processmicrostructure-defect relations that are of importance in L- DED-P processing.