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Influence of Graphene Nanoplatelets on the Performance of Axial Suspension Plasma-Sprayed Hydroxyapatite Coatings.
Centre for Biomaterials, Cellular & Molecular Theranostics (CBCMT), Vellore Institute of Technology, Vellore 632014 (IND).
University West, Department of Engineering Science.
Centre for Biomaterials, Cellular & Molecular Theranostics (CBCMT), Vellore Institute of Technology, Vellore 632014, (IND); School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014 (IND).
Centre for Biomaterials, Cellular & Molecular Theranostics (CBCMT), Vellore Institute of Technology, Vellore 632014, (IND); School of Advanced Sciences, Vellore Institute of Technology, Vellore 632014 (IND).
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2022 (English)In: Bioengineering, E-ISSN 2306-5354, Vol. 10, no 1, p. -22, article id 44Article in journal (Refereed) Published
Abstract [en]

Axial suspension plasma spraying (ASPS) is an alternative technique to atmospheric plasma spraying (APS), which uses a suspension of much finer powders (<5-micron particle size) as the feedstock. It can produce more refined microstructures than APS for biomedical implants. This paper highlights the influence of incorporated graphene nanoplatelets (GNPs) on the behavior of ASPS hydroxyapatite (HAp) coatings. The characterization of the ASPS coatings (HAp + varying GNP contents) was carried out using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), confocal Raman microscopy (CRM), white light interferometry (WLI), and contact angle measurements. The evaluation of the mechanical properties such as the hardness, roughness, adhesion strength, and porosity was carried out, along with a fretting wear performance. Additionally, the biocompatibility of the Hap + GNP coatings was evaluated using cytotoxicity testing which revealed a decrease in the cell viability from 92.7% to 85.4%, with an increase in the GNP wt.%. The visualization of the cell's components was carried out using SEM and Laser Scanning Microscopy. Furthermore, the changes in the genetic expression of the various cellular markers were assessed to analyze the epigenetic changes in human mesenchymal stem cells. The gene expression changes suggested that GNPs upregulated the proliferation marker and downregulated the pluripotent markers by a minimum of three folds.

Place, publisher, year, edition, pages
MDPI, 2022. Vol. 10, no 1, p. -22, article id 44
Keywords [en]
Ti-6Al-4V, biocompatibility, graphene nanoplatelets, hMSCs, hydroxyapatite, plasma axial suspension plasma spraying
National Category
Manufacturing, Surface and Joining Technology
Research subject
Production Technology
Identifiers
URN: urn:nbn:se:hv:diva-19668DOI: 10.3390/bioengineering10010044ISI: 000916974300001PubMedID: 36671618Scopus ID: 2-s2.0-85146748714OAI: oai:DiVA.org:hv-19668DiVA, id: diva2:1796781
Note

This work was supported under the Indo-Swedish Join Network grant, 2019, bythe Department of Science and Technology, India (DST/INT/SWD/VR/P-15/2019) and the SwedishResearch Council (Dnr. 2018-07061). The authors acknowledge Stefan Björklund for helping withthe spraying of coatings and providing valuable suggestions during spraying, as well as FrancisTourenne, MediCoat, France, for providing Hap powder to prepare the suspensions. The authors arethankful to VIT for extending support to perform Raman microscopy

Available from: 2023-09-13 Created: 2023-09-13 Last updated: 2024-02-15

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Joshi, Shrikant V.Markocsan, Nicolaie

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