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Atrial arrhythmias and patient-reported outcomes in adults with congenital heart disease: An international study
Montreal Heart Institute, Université de Montréal, Montreal (CAN).
KU Leuven Department of Public Health and Primary Care, University of Leuven, Leuven (BEL).
Montreal Heart Institute, Université de Montréal, Montreal (CAN).
Montreal Heart Institute, Université de Montréal, Montreal (CAN).
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2021 (English)In: Heart Rhythm, ISSN 1547-5271, E-ISSN 1556-3871, Vol. 18, no 5, p. 793-800Article in journal (Refereed) Published
Abstract [en]

Background Atrial arrhythmias (ie, intra-atrial reentrant tachycardia and atrial fibrillation) are a leading cause of morbidity and hospitalization in adults with congenital heart disease (CHD). Little is known about their effect on quality of life and other patient-reported outcomes (PROs) in adults with CHD. Objective The purpose of this study was to assess the impact of atrial arrhythmias on PROs in adults with CHD and explore geographic variations. Methods Associations between atrial arrhythmias and PROs were assessed in a cross-sectional study of adults with CHD from 15 countries spanning 5 continents. A propensity-based matching weight analysis was performed to compare quality of life, perceived health status, psychological distress, sense of coherence, and illness perception in patients with and those without atrial arrhythmias. Results A total of 4028 adults with CHD were enrolled, 707 (17.6%) of whom had atrial arrhythmias. After applying matching weights, patients with and those without atrial arrhythmias were comparable with regard to age (mean 40.1 vs 40.2 years), demographic variables (52.5% vs 52.2% women), and complexity of CHD (15.9% simple, 44.8% moderate, and 39.2% complex in both groups). Patients with atrial arrhythmias had significantly worse PRO scores with respect to quality of life, perceived health status, psychological distress (ie, depression), and illness perception. A summary score that combines all PRO measures was significantly lower in patients with atrial arrhythmias (-3.3%; P = .0006). Differences in PROs were consistent across geographic regions. Conclusion Atrial arrhythmias in adults with CHD are associated with an adverse impact on a broad range of PROs consistently across various geographic regions.

Place, publisher, year, edition, pages
2021. Vol. 18, no 5, p. 793-800
Keywords [en]
Atrial fibrillation, Congenital heart disease, Intra-atrial reentrant tachycardia, Patient-reported outcomes, Quality of life
National Category
Cardiac and Cardiovascular Systems Nursing
Research subject
NURSING AND PUBLIC HEALTH SCIENCE, Nursing science
Identifiers
URN: urn:nbn:se:hv:diva-18186DOI: 10.1016/j.hrthm.2020.09.012ISI: 000717466400021PubMedID: 32961334Scopus ID: 2-s2.0-85104281510OAI: oai:DiVA.org:hv-18186DiVA, id: diva2:1647740
Funder
Swedish Heart Lung Foundation, 20130607
Note

Funding by:

KU Leuven (OT/11/033)

Cardiac Children's Foundation (Taiwan) (CCF2013_02)

University of Gothenburg Centre for Person-centred Care

(Swedish Heart-Lung Foundation)

Available from: 2022-03-28 Created: 2022-03-28 Last updated: 2022-04-12Bibliographically approved

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Publisher's full textPubMedScopushttps://www.sciencedirect.com/science/article/pii/S1547527120308948

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Berghammer, Malin

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