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Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries
KU Leuven - University of Leuven, KU Leuven Department of Public Health and Primary Care, Leuven,(BEL); Centre for Person-Centred Care (GPCC), Gothenburg, (SWE); University of Gothenburg, Institute of Health and Care Sciences, Gothenburg, (SWE).
KU Leuven - University of Leuven, School Psychology and Child and Adolescent Development,Leuven, (BEL); University of the Free State, UNIBS, Bloemfontein, (ZAF).
KU Leuven Department of Public Health and Primary Care, KU Leuven, Leuven, (BEL);University of Bern, Center for Congenital Heart Disease, Department of Cardiology, Inselspital, Bern University Hospital, Bern,(CHE).
Division of Congenital and Structural Cardiology, University Hospitals Leuven, Leuven, (BEL); KU Leuven - University of Leuven, KU Leuven Department of Cardiovascular Sciences, Leuven,( BEL).
Show others and affiliations
2021 (English)In: Canadian Journal of Cardiology, ISSN 0828-282X, E-ISSN 1916-7075, Vol. 37, no 2, p. 215-223, article id S0828-282X(20)30317-2Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: We compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of congenital heart disease (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects.

METHODS: In the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, and QoL were measured with the SF-12 health status survey, Hospital Anxiety and Depression Scale (HADS), linear analog scale (LAS) and Satisfaction with Life Scale, respectively. Functional class was assessed using the patient-reported New York Heart Association (NYHA) class. Multivariable general linear mixed models were applied to assess the relationship between the type of CHD and patient-reported outcomes, adjusted for patient characteristics, and with country as random effect.

RESULTS: Patients with coarctation of the aorta and those with isolated aortic valve disease reported the best physical functioning, mental health, and QoL. Patients with cyanotic heart disease or Eisenmenger syndrome had worst outcomes. The differences were statistically significant, above and beyond other patient characteristics. However, the explained variances were small (0.6% to 4.1%) and decreased further when functional status was added to the models (0.4% to 0.9%).

CONCLUSIONS: Some types of CHD predict worse patient-reported outcomes. However, it appears that it is the functional status associated with the heart defect rather than the heart defect itself that shapes the outcomes.

Place, publisher, year, edition, pages
2021. Vol. 37, no 2, p. 215-223, article id S0828-282X(20)30317-2
Keywords [en]
Mental health, quality of life
National Category
Nursing Public Health, Global Health, Social Medicine and Epidemiology Cardiac and Cardiovascular Systems
Research subject
NURSING AND PUBLIC HEALTH SCIENCE, Nursing science
Identifiers
URN: urn:nbn:se:hv:diva-15705DOI: 10.1016/j.cjca.2020.03.044ISI: 000620798900014PubMedID: 32739453Scopus ID: 2-s2.0-85089458390OAI: oai:DiVA.org:hv-15705DiVA, id: diva2:1460693
Funder
Swedish Heart Lung Foundation
Note

Funders: Research Funde KU Leuven, Leuven, Belgium[OT/11/033); Cardiac Children’s Foundation, Taiwan[CCF201302]

Available from: 2020-08-24 Created: 2020-08-24 Last updated: 2022-03-30Bibliographically approved

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Berghammer, Malin

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