Background: With a greater life expectancy and patients being discharged from hospitals earlier than before, the health care profession has recognised an increasing need for qualified nurses in the in-home health sector. Health care provided from a patient’s home often expose its own set of challenges, such as offering care on their terms whilst being considerate of their needs. Aim: The aim of this study was to illustrate the experiences faced by nurses while providing care directly from a patient’s home. Method: Through a qualitative literature review where the findings analysed according to a five-step model. The qualitative analysis resulted in 4 main themes and 11 sub-themes. Results: Many nurses experienced heavy workload. Many nurses also felt they sometimes lacked the knowledge required when faced with different situations, highlighting a need for continued learning to improve competency. Relationships were viewed as important for the care sector; including patient, family of the patient and co-workers. The nurses also experienced deep personal involvement in the patient’s life-situation. Conclusion: A common observation made by nurses in the home-based healthcare sector is how a lack of knowledge and experience creates an unsafe work environment. Another important observation was how relationships with patients and their next of kin could make a great improvement to the quality of the homecare given. Many nurses express a huge commitment and duty of care to their patients; a trait which demonstrates great conviction to the nursing occupation.