Background: Multiple myeloma is a malignant incurable cancer disease associated with severe chronic pain. The nurse has several important roles in the management of patients with multiple myeloma. This study focuses on nurse´s roles including the caring of pain relief.

Aim: The aim of this study was to elucidate the nurse’s role in giving care to patients with multiple myeloma and associated chronic pain.

Method: This literature study was based on scientific articles.

Results: The nurse is in a key position to facilitate ongoing adequate pain and psychosocial assessment of patients with multiple myeloma. The study presents ways of relieving pain and suffering via different ways of caring management. Five themes emerged: communication, support, distraction, information and education, pain assessment and evaluation. The nurse´s roles are acknowledged, and associated ethical dilemmas are presented. Knowledge about how to decrease pain and suffering by non-pharmacological means, improves the nurse´s possibility to manage difficult situations in patients with incurable cancer.