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Hoppe, M., Hulthén, L. & Samuelson, G. (2019). Is cord blood hepcidin influenced by the low-grade acute-phase response occurring during delivery?: A small-scale longitudinal study. The Journal of Maternal-Fetal & Neonatal Medicine, 32(13), 2166-2172
Open this publication in new window or tab >>Is cord blood hepcidin influenced by the low-grade acute-phase response occurring during delivery?: A small-scale longitudinal study
2019 (English)In: The Journal of Maternal-Fetal & Neonatal Medicine, ISSN 1476-7058, E-ISSN 1476-4954, Vol. 32, no 13, p. 2166-2172Article in journal (Refereed) Published
Abstract [en]

AIM: To measure serum hepcidin in late pregnancy and in cord blood, and to analyze relationship between hepcidin, interleukin-6 and biomarkers of fetal iron status.

MATERIALS AND METHODS: Data from 15 uncomplicated singleton pregnancies were analyzed longitudinally in trimester 3 (T3) and at birth.

RESULTS: In T3, S-ferritin (median 14 µg/L) and transferrin (median 4.0 g/L) indicated low iron status, whereas the median soluble transferrin receptor (sTfR) was 4.0 mg/L, ie within the reference interval. Median T3 S-hepcidin was 7.8 ng/mL. Later on in cord blood, ferritin concentration (180 µg/L) were significantly higher, transferrin concentration (1.8 g/L) were significantly lower, and both sTfR (4.7 mg/L) and S-hepcidin concentrations (30.5 ng/mL) were significantly higher than maternal T3 concentrations. At the same time, cord blood interleukin-6 indicated an activated acute-phase reaction. In T3, after logarithmic transformation, there was a significant correlation between S-hepcidin and both S-ferritin (r = 0.691) and sTfR (r = -0.825). There was also a significant correlation between S-ferritin and both sTfR (r = -0.729) and transferrin (r = 0.549) in T3.

CONCLUSIONS: Although S-ferritin, S-hepcidin, and sTfR were correlated during pregnancy, these relationships were not apparent in umbilical cord blood. Further, cord blood interleukin-6 indicated an activated acute-phase response, and sTfR, which is known to be unaffected by inflammation, indicated a low iron status in cord blood. Thus, instead of representing an enhanced iron status, the data appear to suggest that hepcidin and ferritin in cord blood may be influenced by the low-grade acute-phase response that occurs during delivery.

Keywords
Cord blood, ferritin, hepcidin, iron, pregnancy
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
NURSING AND PUBLIC HEALTH SCIENCE, Nursing science
Identifiers
urn:nbn:se:hv:diva-12006 (URN)10.1080/14767058.2018.1427723 (DOI)000462848000008 ()29325459 (PubMedID)2-s2.0-85040977269 (Scopus ID)
Funder
Region Västra Götaland, VGFOUREG-28141
Note

Funders: Frimurare-Barnhusdirektionen, GLS-47931; Mary von Sydow Foundation 

Available from: 2018-01-16 Created: 2018-01-16 Last updated: 2019-05-10Bibliographically approved
Larsson, I., Lissner, L., Samuelson, G., Fors, H., Lantz, H., Näslund, I., . . . Bosaeus, I. (2015). Body composition through adult life: Swedish reference data on body composition. European Journal of Clinical Nutrition, 69(7), 837-842
Open this publication in new window or tab >>Body composition through adult life: Swedish reference data on body composition
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2015 (English)In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 69, no 7, p. 837-842Article in journal (Refereed) Published
Abstract [en]

Background/Objectives:The prevalence of obesity, defined as body mass index (BMI) greater than or equal to30 kg/m2, differs between populations; however, there is a need for data on description on body composition in reference populations of different ages and from different countries. The objective of this study was to pool dual-energy X-ray absorptiometry (DXA) body composition reference data from population-based Swedish cohorts.Subjects/Methods:Four population-based cross-sectional cohort studies including 1424 adult Swedes were divided into five age groups (20–29, 30–39, 40–49, 50–61 and 75 years of age); BMI 24.6±3.9 kg/m2 were pooled. Body composition was measured with DXA.

Results:The difference in BMI from the youngest to the oldest age group was 3.2 and 4.3 kg/m2 in men and women, respectively (P<0.001, both sexes), and fat mass (FM) was 9.9 and 9.1% higher in the oldest compared with the youngest men and women (P<0.001, both sexes). Fat-free mass (FFM) remained stable up to 60 years of age in men (P=0.83) and was lower at 75 years of age compared with the younger ages. In women, FFM was lower from age 60. From youngest to oldest age groups, height-adjusted FM differed from 4.6 to 7.8 kg/m2 in men and from 6.8 to 10.8 kg/m2 in women (P<0.001, both sexes).

Conclusions:Our results provide reference data on body composition in Swedish populations. BMI and FM were higher among older age groups compared with the younger ones. FFM remained stable up to 60 years of age and was lower first among the 75 years of age.

Keywords
Obesity, body mass index (BMI)
National Category
Other Health Sciences
Research subject
NURSING AND PUBLIC HEALTH SCIENCE, Public health science
Identifiers
urn:nbn:se:hv:diva-7255 (URN)10.1038/ejcn.2014.268 (DOI)000357290200014 ()25514897 (PubMedID)2-s2.0-84934438674 (Scopus ID)
Note

Professor Gösta Samuelson samlade trycksaker; 163

Available from: 2015-01-09 Created: 2015-01-08 Last updated: 2019-03-05Bibliographically approved
Tryggvason, N., Sorbring, E. & Samuelson, G. (2012). Unga föräldrar: identitet, möjligheter och utmaningar (1. uppl.ed.). Malmö: Liber
Open this publication in new window or tab >>Unga föräldrar: identitet, möjligheter och utmaningar
2012 (Swedish)Book (Other academic)
Place, publisher, year, edition, pages
Malmö: Liber, 2012. p. 197 Edition: 1. uppl.
Keywords
Teenage mothers, Tonårsmödrar
National Category
Psychology (excluding Applied Psychology) Social Work
Research subject
SOCIAL SCIENCE, Sociology; SOCIAL SCIENCE, Psychology
Identifiers
urn:nbn:se:hv:diva-4543 (URN)978-91-47-09781-4 (ISBN)
Note

Professor Gösta Samuelson samlade trycksaker; 192

Available from: 2012-08-17 Created: 2012-08-17 Last updated: 2019-04-12Bibliographically approved
Lantz, H., Brattby, L.-E., Fors, H., Sandhagen, B., Sjöström, L. & Samuelson, G. (2008). Body composition in a cohort of Swedish adolescents aged 15, 17 and 20.5 years. Acta Paediatrica, 97(12), 1691-1697
Open this publication in new window or tab >>Body composition in a cohort of Swedish adolescents aged 15, 17 and 20.5 years
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2008 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 97, no 12, p. 1691-1697Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Wiley-Blackwell Publishing, 2008
Keywords
Adolescence, Body compartments, DXA, Energy expenditure, Socio-economic conditions
National Category
Nursing Public Health, Global Health, Social Medicine and Epidemiology
Research subject
NURSING AND PUBLIC HEALTH SCIENCE, Nursing science
Identifiers
urn:nbn:se:hv:diva-1516 (URN)10.1111/j.1651-2227.2008.01035.x (DOI)
Note

Professor Gösta Samuelson samlade trycksaker; 191

Available from: 2009-05-11 Created: 2009-05-11 Last updated: 2019-04-12Bibliographically approved
Samuelson, G., Åman, J., Lodefalk, M., Detlofsson, I., Cederholm, U. & Vall, H. (2008). Mat vid diabetes. In: Barn och ungdomsdiabetes (pp. 93-102). Lund: Studentlitteratur
Open this publication in new window or tab >>Mat vid diabetes
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2008 (Swedish)In: Barn och ungdomsdiabetes, Lund: Studentlitteratur , 2008, p. 93-102Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur, 2008
National Category
Nutrition and Dietetics
Research subject
NURSING AND PUBLIC HEALTH SCIENCE, Nursing science
Identifiers
urn:nbn:se:hv:diva-1933 (URN)978-91-44-04929-8 (ISBN)
Available from: 2009-11-11 Created: 2009-11-10 Last updated: 2015-01-19Bibliographically approved
Samuelson, G. (2007). Övervikt och fetma hos barn. Barnbladet, 32(1), 8-10
Open this publication in new window or tab >>Övervikt och fetma hos barn
2007 (Swedish)In: Barnbladet, ISSN 0349-1994, Vol. 32, no 1, p. 8-10Article in journal (Other (popular science, discussion, etc.)) Published
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:hv:diva-13233 (URN)
Note

Professor Gösta Samuelson samlade trycksaker; 164

Available from: 2018-12-18 Created: 2018-12-18 Last updated: 2019-03-05Bibliographically approved
Bárány, E., Bergdahl, I. A., Bratteby, L.-E., Lundh, T., Samuelson, G., Skerfving, S. & Oskarsson, A. (2005). Iron status influences trace element levels in human blood and serum.. Environmental Research, 98(2), 215-23
Open this publication in new window or tab >>Iron status influences trace element levels in human blood and serum.
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2005 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 98, no 2, p. 215-23Article in journal (Refereed) Published
Abstract [en]

Food is the main source of trace elements for the general population. The gastrointestinal absorption of certain trace elements, e.g., cadmium, is strongly influenced by iron (Fe) status. This factor may also be relevant for the bioavailability of other trace elements. Therefore, we investigated relationships between Fe status indicators and trace element concentrations in blood and serum of 234 boys and girls at ages 15 and 17 years. Fe status was measured using serum ferritin (S-Ft), soluble transferrin receptor in serum (sTfR), and the ratio sTfR/S-Ft. The trace elements we investigated were, in blood, cadmium, cobalt, copper, zinc, selenium, rubidium, mercury, and lead, and, in serum, cobalt, copper, zinc, selenium, rubidium, tungsten, mercury, and lead. We found inverse correlations between Fe status and blood cadmium, blood or serum cobalt, or blood copper. There were positive correlations between Fe status and mercury concentrations. Selenium was positively correlated with sTfR. The relationships between Fe status and lead were equivocal. There were fewer correlations for serum than for blood, but the inverse relationships between Fe status and cobalt were equally strong in serum and blood. We found only occasional, and perhaps spurious, correlations with zinc, rubidium, and tungsten. In conclusion, previous indications that cadmium, cobalt, and copper are absorbed by transport mechanisms similar to that of Fe are supported by this study. Strong positive correlations between Fe status and mercury concentrations remain to be explained.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:hv:diva-10877 (URN)10.1016/j.envres.2004.09.010 (DOI)15820728 (PubMedID)
Note

Professor Gösta Samuelson samlade trycksaker; 189

Available from: 2018-12-19 Created: 2018-12-19 Last updated: 2019-04-12Bibliographically approved
Bratteby, L.-E., Sandhagen, B. & Samuelson, G. (2005). Physical activity, energy expenditure and their correlates in two cohorts of Swedish subjects between adolescence and early adulthood. European Journal of Clinical Nutrition, 59(11), 1324-34
Open this publication in new window or tab >>Physical activity, energy expenditure and their correlates in two cohorts of Swedish subjects between adolescence and early adulthood
2005 (English)In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 59, no 11, p. 1324-34Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To assess physical activity and energy expenditure and to identify their correlates during adolescence and early adulthood. DESIGN: In a cohort study, total energy expenditure (TEE) and physical activity level (PAL) were assessed at 15 and 21 y from a 7-day activity diary and predicted BMR. The influences on TEE and PAL of body size, gender, sexual maturity, physical activity habits, sitting time, region, social conditions, employment, food habits, smoking and alcohol intake were examined in multivariate analyses.Subjects:71 male and 89 female subjects, living in two socioeconomically different regions of Sweden, a university region and an industrial region. SETTING: The university city of Uppsala and the industrial town of Trollhättan. RESULTS: At both 15 and 21 y, PAL and TEE were high, with gender, sitting time and physical activity habits as main correlates. At age 21 y, employment and the mother's educational level also appeared as significant correlates. The relations between the main variables and their correlates were more complex than at age 15 y, and the sitting time was reduced and the activity habits were changed. CONCLUSIONS: A reduction of daily sitting appears to be a major reason why high levels of physical activity and energy expenditure were maintained from 15 to 21 y of age in spite of changed and less frequent activity habits during this interval.

Keywords
adolescents, physical activity, energy expenditure, sedentary life style
National Category
Nutrition and Dietetics
Research subject
NURSING AND PUBLIC HEALTH SCIENCE, Nursing science
Identifiers
urn:nbn:se:hv:diva-1749 (URN)10.1038/sj.ejcn.1602246 (DOI)16091767 (PubMedID)
Note

Professor Gösta Samuelson samlade trycksaker; 190

Available from: 2009-10-05 Created: 2009-10-02 Last updated: 2019-04-12Bibliographically approved
Samuelson, G. (2004). Global strategy on diet, physical activity and health. Scandinavian Journal of Nutrition/Næringsforskning, 57-57
Open this publication in new window or tab >>Global strategy on diet, physical activity and health
2004 (English)In: Scandinavian Journal of Nutrition/Næringsforskning, ISSN 1102-6480, E-ISSN 1651-2359, p. 57-57Article in journal, Editorial material (Refereed) Published
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:hv:diva-13234 (URN)10.3402/fnr.v48i2.1503 (DOI)
Available from: 2018-12-18 Created: 2018-12-18 Last updated: 2019-04-15Bibliographically approved
Hellerud, C., Wramner, N., Erikson, A., Johansson, A., Samuelson, G. & Lindstedt, S. (2004). Glycerol kinase deficiency: follow-up during 20 years, genetics, biochemistry and prognosis.. Acta Paediatrica, 93(7), 911-21
Open this publication in new window or tab >>Glycerol kinase deficiency: follow-up during 20 years, genetics, biochemistry and prognosis.
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2004 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 93, no 7, p. 911-21Article in journal (Refereed) Published
Abstract [en]

AIM: To follow two children with isolated glycerol kinase deficiency (GKD) with severe symptoms into adulthood.

METHODS: The patients were followed during approximately 20 y and interviewed about symptoms, diet and physical activity. Fasting provocations, bicycle ergometer tests, dietary registrations, enzyme and mutation analysis were performed by standard protocols.

RESULTS: The activity of glycerol kinase (GK) in fibroblasts was <10% of reference. One case had a deletion of exon 17, the other a mutation in exon 7 of the GK gene (601 A-->G). Both mothers were heterozygotes. Two maternal male cousins in one of the families were hemizygotes without symptoms. Tests performed in childhood documented pronounced sensitivity to fasting and physical exercise, whereas such tests at 23 and 31 y of age were essentially normal but with pronounced ketonaemia. After puberty, the boys had no hypoglycaemic symptoms and now report no problems with their condition; thus, their phenotype has changed over time.

CONCLUSION: The greater importance of glycerol as a gluconeogenetic substrate in children than in adults may explain the episodes in young patients with GKD, often elicited by catabolic stress. With meals at frequent intervals, access to glucose and avoidance of strenuous sports, the prognosis is good for a normal adult life of a young child with isolated GKD and symptoms of hypoglycaemia.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:hv:diva-13225 (URN)10.1111/j.1651-2227.2004.tb02689.x (DOI)15303806 (PubMedID)
Note

Professor Gösta Samuelson samlade trycksaker; 161

Available from: 2018-12-18 Created: 2018-12-18 Last updated: 2019-03-05Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-7328-2190

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